Table 3. Top ten three-way interactions found in the analysis of the ever smokers.

SNP combination	OR (95% CI)	P-value
rs8102137 [C/T, T/T] × rs11892031 [A/A] × GSTM1 null	1.58 (1.30–1.92)	0.0059
rs710521 [A/A, A/G] × rs11892031 [A/A] × GSTM1 null	1.51 (1.26–1.80)	0.0080
rs710521 [A/A, A/G] × rs8102137 [C/T, T/T] × GSTM1 null	1.55 (1.28–1.88)	0.0135
rs9642880 [G/G, G/T] × rs710521 [A/A, A/G] × GSTM1 present	0.66 (0.55–0.79)	0.0171
rs8102137 [C/T, T/T] × rs1495741 [A/A, A/G] × GSTM1 null	1.52 (1.26–1.84)	0.0248
rs8102137 [C/T, T/T] × rs11892031 [A/A, A/C] × GSTM1 null	1.50 (1.25–1.81)	0.0315
rs1014971 [C/C, C/T] × rs11892031 [A/A] × GSTM1 null	1.46 (1.22–1.74)	0.0419
rs9642880 [G/G, G/T] × rs11892031 [A/A, A/C] × GSTM1 present	0.68 (0.57–0.82)	0.0520
rs710521 [A/A, A/G] × rs11892031 [A/A, A/C] × GSTM1 null	1.45 (1.22–1.72)	0.0552
rs710521 [A/A, A/G] × rs1014971 [C/C, C/T] × GSTM1 present	0.69 (0.57–0.82)	0.0582

The top ten of the 1,760 possible three-way interactions comprised of the six SNPs and GSTM1, as well as their odds ratios (OR) with 95% confidence intervals (CI) are listed in order of their p-values, where the p-values were adjusted for multiple comparisons by the Bonferroni correction.