Table 4. Top ten three-way interactions found in the analysis of the non-smokers.

SNP combination	OR (95% CI)	P-value
rs9642880 [G/T, T/T] × rs710521 [A/A, A/G] × rs1014971 [C/C]	1.98 (1.49–2.63)	0.0044
rs9642880 [G/T, T/T] × rs1014971 [C/C] × rs1495741 [A/A, A/G]	1.95 (1.47–2.58)	0.0054
rs9642880 [G/T, T/T] × rs1014971 [C/C] × rs11892031 [A/A, A/C]	1.93 (1.46–2.55)	0.0061
rs9642880 [G/T, T/T] × rs1014971 [C/C] × GSTM1 null	2.21 (1.58–3.10)	0.0070
rs9642880 [G/G, G/T] × rs1014971 [C/T, T/T] × rs8102137 [C/C, C/T]	0.54 (0.40–0.71)	0.0318
rs9642880 [G/G, G/T] × rs710521 [A/A, A/G] × rs1014971 [C/T, T/T]	0.54 (0.40–0.71)	0.0325
rs9642880 [G/G, G/T] × rs1014971 [C/T, T/T] × rs1495741 [A/A, A/G]	0.56 (0.42–0.74)	0.0735
rs710521 [A/A, A/G] × rs1014971 [C/C] × GSTM1 null	1.93 (1.41–2.64)	0.0773
rs9642880 [G/T, T/T] × rs1014971 [C/C] × rs11892031 [A/A]	1.80 (1.35–2.40)	0.0954
rs710521 [A/A, A/G] × rs1014971 [C/C] × rs11892031 [A/A]	1.74 (1.33–2.29)	0.1142

The top ten of the 1,760 possible three-way interactions comprised of the six SNPs and GSTM1, as well as their odds ratios (OR) with 95% confidence intervals (CI) are listed in order of their p-values, where the p-values were adjusted for multiple comparisons by the Bonferroni correction.