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. 2012 Dec 20;7(12):e51610. doi: 10.1371/journal.pone.0051610

Figure 4. TEA sensitivity of the outward current as a function of postnatal day.

Figure 4

(A) The reduction of the outward current to 20 mM TEA was assayed with the protocol in figure 7. (B) Comparison of the differences in pharmacology for the total non-inactivating outward current, between early (P0) and late (P7–P15) SN DA neurons. Experimental protocol as explained in figure legends 5 & 6. Control conductance (Left white bar, G(Control, P0)Inline graphic nS, n = 10). At P0 the currents are insensitive to 20 mM TEA (Left Black bar, G(TEA, P0)Inline graphic nS, n = 4), 1 Inline graphicm CbTx (Left hatch bar, G(CbTx, P0)Inline graphic nS, n = 3) and 1 Inline graphicm IbTx (left criss-cross bar, G(IbTx, P0)Inline graphic nS, n = 2). Average control conductance pooled from P7 to P15 (Right white bar, G(Control, P7–P15)Inline graphic nS, n = 23). Effect of 20 mM TEA on the conductance from P7–P15 (Right black bar (G(TEA, P7–P15)Inline graphic nS, n = 10). Effects of 1 Inline graphicm CbTx (Right hatch bar G(CbTx, P7–P15)Inline graphic nS, n = 3) and 1 Inline graphicM IbTx (Right criss-cross bar, G(IbTx)Inline graphic nS, n = 2) on the conductance, data pooled from P7 to P15.