Figure 3. Effect of RNS60, NS, PNS60, and RNS10.3 on the expression of iNOS in MBP-primed LNC.

LNC isolated from MBP-immunized mice were stimulated with MBP for 24 h in the presence of 10% (v/v) of RNS60, NS, RNS10.3, or PNS60 followed by monitoring the level of nitrite (A) and the expression of iNOS mRNAs by semi-quantitative RT-PCR (B). Results are mean ± SD of three different experiments. ^ap<0.0001 versus control; ^bp<0.0001 versus MBP.