Figure 7. Effect of RNS60 on clinical symptoms of adoptively-transferred relapsing-remitting EAE in mice and encephalitogenicity of MBP-primed T cells.

A) EAE was induced in female SJL/J mice by adoptive transfer of MBP-primed T cells. From 0 dpt, mice were treated with different doses of RNS60 or NS via i.p. injection (dpt 1–8, alternate day; dpt 9–16, daily; dpt 17 onwards, alternate day). Five mice were included in each group. Mice (n = 5) were examined for clinical symptoms daily until 42 dpt. B) MBP-primed T cells isolated from female SJL/J donor mice were treated with either RNS60 or NS during MBP re-priming for 4 d followed by tail vein injection of MBP-primed T cells into naïve female SJL/J mice. Five mice were included in each group.