Figure 8. RNS60 inhibits the progression of adoptively-transferred relapsing-remitting EAE in mice.
EAE was induced in female SJL/J mice by adoptive transfer of MBP-primed T cells. A) From the onset of acute phase (8 dpt), mice were treated with either RNS60 or NS via i.p. injection (dpt 8–16, daily; dpt 17 onwards, alternate day). Mice (n = 5) were examined for clinical symptoms everyday until 45 dpt. B) From the onset of relapsing-remitting phase (22 dpt), mice were treated with either RNS60 or NS via i.p. injection (alternate day). Mice (n = 5) were examined for clinical symptoms daily until 54 dpt.