. 2012 Dec 20;7(12):e51869. doi: 10.1371/journal.pone.0051869

Table 1. Effect of RNS60 and NS on clinical symptoms of EAE.

Treatment	Incidence	Mean peak clinical score	Suppression of EAE
			Incidence	Score
EAE	6/6	3.6
EAE+RNS60 (100 µl/mouse/d)	5/5	2.0	0	44^b
EAE+RNS60 (200 µl/mouse/d)	4/5	1.5	20	58^a
EAE+RNS60 (300 µl/mouse/d)	2/5	0.8	60^a	78^a
EAE+NS (300 µl/mouse/d)	5/5	3.5	0	3

EAE was induced in female SJL/J mice through adoptive transfer of MBP-primed T cells. From 0 dpt, mice were treated with different doses of RNS60 or NS via i.p. injection (dpt 1–8, alternate day; dpt 9–16, daily; dpt 17 onwards, alternate day). While a clinical score of 1 was considered as the incidence of EAE in mice, a clinical score of 0 was considered to be normal.

p<0.001,

p<0.01 vs EAE (control).