Table 1. Characteristics of the patients classified into low- and high- adiponectin levels.
| Characteristic | Low adiponectin | High adiponectin | P | Adjusted* | |
| (n = 25) | (n = 49) | R | P | ||
| Epidemiologic and clinical | |||||
| Age (yr) | 58±13 | 62±15 | 0.240 | – | – |
| Sex (males/females %) | 56/44 | 55.1/44.9 | 0.941 | – | – |
| Diabetes (%) | 16 | 20.4 | 0.647 | – | – |
| CVD (%) | 24 | 18.4 | 0.569 | – | – |
| Dialysis mode (HD/PD %) | 60/40 | 65.3/34.7 | 0.654 | – | – |
| RRT vintage (months) | 61±56 | 68±44 | 0.556 | – | – |
| Dialysate Ca (Low/High %) | 36/49.9 | 64/53.1 | 0.369 | – | – |
| Mean arterial pressure (mmHg) | 94±14 | 94±17 | 0.978 | – | – |
| Hypertension (%) | 56 | 63.3 | 0.545 | – | – |
| β-Blockers (%) | 16 | 6.1 | 0.170 | – | – |
| ACEIs +ARBs (%) | 44.4 | 28.6 | 0.184 | – | – |
| CCB (%) | 24 | 26.5 | 0.814 | – | – |
| Death from all causes (%) | 8 | 32.7 | 0.023 | – | – |
| Anthropometric | |||||
| Body mass index (Kg/m2) | 28.1±2.7 | 24.7±3.1 | <0.001 | −0.120 | 0.311 |
| Fat mass index (Kg/m2) | 10.7±2.5 | 8.5±3.0 | 0.003 | – | – |
| Fat-free mass index (Kg/m2) | 17.4±1.7 | 16.2±2.2 | 0.016 | −0.120 | 0.312 |
| Waist circumference (cm) | 102.4±9.9 | 90.9±9.6 | 0.000 | −0.317 | 0.006 |
| Triceps skinfold thickness (cm | 1.8±0.8 | 1.4±0.7 | 0.049 | 0.002 | 0.984 |
| Mid-arm circumference (cm) | 30.9±3.6 | 27.9±4.1 | 0.003 | −0.232 | 0.048 |
| Mid-arm muscle circumference (cm) | 25.3±3.6 | 23.4±3.4 | 0.034 | −0.246 | 0.036 |
| Arm muscle area (cm2) | 51.9±15.8 | 44.7±13.2 | 0.042 | −0.238 | 0.042 |
| Inflammatory | |||||
| C-reactive protein (mg/dl) | 0.37 (0.3–1.3) | 0.46 (0.3–1.2) | 0.909 | −0.131 | 0.268 |
| Interleukin-6 (pg/ml) | 5.3(3.2–9.0) | 5.8 (4.3–11.3) | 0.346 | 0.011 | 0.926 |
| Interleukin-8 (pg/ml) | 10.5 (6.9–19) | 13.8 (10–22.4) | 0.141 | 0.266 | 0.023 |
| Nutritional and biochemical | |||||
| Albumin (g/dl) | 4.0±0.36 | 3.85±0.46 | 0.156 | −0.331 | 0.004 |
| Prealbumin (mg/dl) | 30±12 | 27±9 | 0.197 | −0.109 | 0.357 |
| Transferrin (mg/dl) | 173±41 | 164±34 | 0.329 | −0.004 | 0.970 |
| Hemoglobin (g/dl) | 11.9±1.2 | 11.8±1.4 | 0.883 | −0.056 | 0.643 |
| Creatinine (mg/dl) | 8.2±2.7 | 8.9±2.7 | 0.924 | −0.166 | 0.159 |
| Total Cholesterol (mg/dl) | 174±3.3 | 171±41 | 0.407 | 0.199 | 0.091 |
| HDL cholesterol (mg/dl) | 42±14 | 50±1 5 | 0.044 | 0.207 | 0.079 |
| LDL cholesterol (mg/dl) | 84±25 | 85±37 | 0.920 | 0.251 | 0.032 |
| Triglycerides (mg/dl) | 207 (160–311) | 166 (99–216) | 0.001 | −0.137 | 0.285 |
| Parathormone (pg/ml) | 121 (61–205) | 121 (58–169) | 0.773 | −0.101 | 0.395 |
| Calcium (mg/dl) | 9.3±0.8 | 9.2±0.8 | 0.560 | −0.293 | 0.012 |
| Magnesium (mg/dl) | 2.4±0.4 | 2.6±0.5 | 0.247 | 0.288 | 0.014 |
| Phosphorus (mg/dl) | 5.2±1.2 | 5.1±1.1 | 0.701 | −0.076 | 0.581 |
| Adiponectin (µg/ml) | 11.7 (9.7–14.3) | 23.5 (20–34.1) | <0.001 | – | |
Values expressed as mean ± SD or median (interquartile range).
CVD, cardiovascular disease; HD, hemodialysis; PD, peritoneal dialysis; RRT, renal replacement therapy; ACEI’s, angiotensin-converting enzyme inhibitors; ARBs, angiotensin receptor blockers; CCB, calcium channel blockers.
*
Partial coefficients of correlations between adiponectin and baseline characteristics (anthropometric, inflammatory and nutritional) after correction for fat mass index.