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. 2012 Dec 20;7(12):e52356. doi: 10.1371/journal.pone.0052356

Figure 5. Silencing of Cdk2 and suppression of cell proliferation by the Cdk2i scaffold.

Figure 5

The effectiveness of the plasmid DNA containing scaffolds was tested on MCF-7 cells growing directly on them. Control scaffold and those containing plasmid DNA encoding for Cdk2 (Cdk2i) or EGFP (EGFPi) shRNA, both in terms of suppressing Cdk2 mRNA, as measured by Q-PCR on culture day 4 (A) and cellular proliferation, as measured by the MTS assay on culture day 1 (B). The Control and EGFPi scaffolds served as controls in both experiments. (A) *p<.01, **p<.04. (B) *p<.02, **p<.001.