Table 1. Association study for TNF-α promoter polymorphisms in patients with generalized vitiligo from Gujarat.
| SNP | Genotype or allele | Generalized VitiligoPatients (Freq.) | Controls (Freq.) | p forAssociation | p for HWE | Odds ratio (95% CI) |
| rs361525(−238; G/A) | GenotypeGGGAAAAlleleGA | (n = 729)250 (0.34)339 (0.47)140 (0.19)839 (0.58)619 (0.42) | (n = 990)798 (0.81)178 (0.18)14 (0.01)1774 (0.90)206 (0.10) | <0.0001<0.0001 | 0.192(P)0.263(C) | 6.35 (5.320–7.590) |
| rs1800629(−308; G/A) | GenotypeGGGAAAAlleleGA | (n = 728)317 (0.44)311 (0.43)100 (0.13)945 (0.65)511 (0.35) | (n = 981)780 (0.80)184 (0.19)17 (0.01)1744 (0.89)218 (0.11) | <0.0001<0.0001 | 0.093(P)0.114(C) | 4.326 (3.623–5.165) |
| rs1799724(−857; C/T) | GenotypeCCCTTTAlleleCT | (n = 728)249 (0.34)347 (0.48)132 (0.18)845 (0.58)611 (0.42) | (n = 984)563 (0.57)352 (0.36)69 (0.07)1478 (0.75)490 (0.25) | <0.0001<0.0001 | 0.563(P)0.173(C) | 2.181 (1.885–2.524) |
| rs1800630(−863; C/A) | GenotypeCCCAAAAlleleCA | (n = 728)365 (0.50)287 (0.40)76 (0.10)1017 (0.70)439 (0.30) | (n = 984)698 (0.71)253 (0.26)33 (0.03)1649 (0.84)319 (0.16) | <0.0001<0.0001 | 0.084(P)0.094(C) | 2.231 (1.894–2.629) |
| rs1799964(−1031; T/C) | GenotypeTTTCCCAlleleTC | (n = 733)354 (0.48)295 (0.40)84 (0.12)1003 (0.68)463 (0.32) | (n = 989)653 (0.66)295 (0.30)41 (0.04)1601 (0.81)377 (0.19) | <0.0001<0.0001 | 0.063(P)0.296(C) | 1.960 (1.675–2.294) |
‘n’ represents number of Patients/Controls,
HWE refers to Hardy-Weinberg Equilibrium,
CI refers to Confidence Interval,
(P) refers to Patients and (C) refers to Controls,
Statistical significance was considered at p value ≤0.01 due to Bonferroni’s correction for multiple testing.