Figure 4. MN10021-mediated inhibition of vascular leak in murine DIC model.

Two groups of 5 CD-1 mice (male, 6–8 weeks of age) were each injected i.p with 1.0 ml of either saline or 1.0 ml of the indicated dose of MN10021 in saline. Twelve hours later the mice were each injected i.v. with 0.25 ml of saline containing 10⁶ cpm of [¹²⁵I]-BSA followed by an i.p. injection of 1.0 ml of either saline or 1.0% carrageenan. Twelve hours later the mice were euthanized, the lungs removed, and the lung associated radioactivity determined by gamma scintillation spectrophotometry. The increases in lung associated radioactivity was calculated as There were no differences in lung-associated radioactivity in mice (whether treated with MN10021 or not) injected i.p. with saline. The data plotted are the mean ± SE of the 5 measurements made. ** p<0.01; * p<0.05; NS  =  not significant.