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Three SHR rats were orally-dosed (by gavage) with MN10021 (100 mg/kg) prepared in 2% Tween 80/distilled water. Systolic blood pressure (BP) measurements were made using a tail-cuff manometer at 0, 1, 2, and 4 h. L-methyldopa (100 mg/kg) was used as a positive control. The percent reduction in BP is calculated based on the 0 h value and is expressed as a mean ± SE. The experiment shown is representative of two separate experiments.
