Table 1. Pharmacological Profile of MN10021.
Mediator/Function* | MN10021 | MN20050 |
IC50 (µM) | ||
TNF-α | 6.2 | NE |
IL-1β | 17 | NE |
IL-6 | NE | NE |
GM-CSF | 8 | NE |
LTB4 | 6.2 | NE |
PAF | 12.5 | NE |
TF | 12.5 | NE |
Chemotaxis | 0.25 | NE |
Adhesion | NE | NE |
Platelet Aggregation | 5 | NE |
NE = No Effect.
Methods used described in Methods S1.