Table 2. Potency of MN10021 in Mouse Peritonitis Model of Inflammation.
Agent | Maximum Inhibition (%) | Dose Achieving Maximum Inhibition (µg/nmoles) | IC50 (µg/nmoles) |
Dexamethasone | 75 | 80/204 | ND |
Acetaminophen | 95 | 1000/6614 | 20/132 |
Diclofenac | 90 | 100/314 | 5/16 |
MN10021 | 70 | 4/1 | 0.4/0.1 |
MN20050 | NE | NA | NA |
ND = Not Determined.
NE = No Effect.
NA = Not Applicable.