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. 2012 Dec 20;7(12):e52718. doi: 10.1371/journal.pone.0052718

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© 2012 Klenke et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) mean log expression value plot. The most prominent hits are shown in red. Microarray analysis revealed that the expression of genes, such as PI3, SPRR1B, LCN2 (lipocalin 2), MMP1, MMP9, MMP10, MMP12, SPP1, GJB2, Bcl-xl (BCL2L1), cIAP2 (BIRC3), S100A7A (koebnerisin), S100A9, SERPINB3, CEACAM6, KRT6B and SERPINB4 is higher in cholesteatoma compared to external auditory canal skin. Genes like TFAP2B, CDH18, CDH19, PRPH, ID4, PAX3, LAMC2, SP5 and FGFBP2 were significantly down-regulated. (B) Up-regulated and down-regulated genes in cholesteatoma, according to biological function. Biological processes, which are denoted with ‘others’ are processes with less than 10 genes involved.