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. 2012 Dec 20;7(12):e52718. doi: 10.1371/journal.pone.0052718

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© 2012 Klenke et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Proteins are the nodes and the edges are protein activation/inactivations, such as phosphorylation and dephosphorylation across a set of proteins. The cytokeratin analysis reveals an up-regulation of Keratin 6 A and B, Keratin18, Keratin 19 and Keratin 81. In our data, genes for Keratin 15, FAM107A, BBS1 and Peripherin were down-regulated in cholesteatoma. Colors: red: up-reglated genes within cholesteatoma compared to external auditory skin; green: down-regulated genes within cholesteatoma compared to external auditory skin; grey: the gene for the protein is not in the microarray; Node-Size: The “Node Ranking” describes the number of interactions. The bigger the nodes, the more interactions are represented for the protein in the network.