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. 2012 Dec 20;7(12):e52718. doi: 10.1371/journal.pone.0052718

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© 2012 Klenke et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Proteins are the nodes and the edges are protein activation/inactivations, such as phosphorylation and dephosphorylation across a set of proteins. The S100 Network shows an up-regulation of S100A7, S100A8 and S100A9 as well as ILK and IκB, USF2 and ARRB2. In which NUAK1 seems to be down-regulated. Different colors showing the expression of genes with the cholesteatoma compared to external auditory skin: red: up-regulated; green: down-regulated; grey: the gene for the protein is not in the microarray; Node-Size also called “Node Ranking” describes the number of interactions. The bigger the nodes, the more interactions are represented for the protein in the network.