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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Wiley Interdiscip Rev Syst Biol Med. 2012 Nov 13;5(1):37–53. doi: 10.1002/wsbm.1196

Table 1.

Summary of memory enhancement effects presented in the present review, including species and tasks tested.

Name Species Tasks Relevant
References

CREB-C/EBP Pathway
CREB Aplysia Synaptic facilitation 24
Drosophila Conditioned odor avoidance 25
  Downstream Rodent Fear potentiated startle, water maze 26,27
    C/EBP
Aplysia Synaptic Facilitation 29
Rodent MWM 30
    IGF-II Rodent IA, CFC, Extinction 36,89
  Upstream
    MAPK 31
    PKA 31
    cAMP 31
    Calcineurin Aplysia Tail-shock sensitization 34
Rodent nOR, MWM, radial arm maze 33
    PDE4 Rodent CFC 35

Synaptic Remodeling
NMDA
Rodent nOR, AFC, CFC, Extinction, MWM 39,47
working memory 40
    D-Cycloserine Human FC (cued fear conditioning) 46
AMPA
    Ampakines Rodent AFC 52
NHP Delayed-non-match-to-Sample 52
Human Delayed Recall 52
    PKMzeta Rodent Conditioned Taste Aversion 50
Arc Rodent IA 36,56
CNF1 Rodent MWM, AFC 58
NCAM Rodent MWM, AFC 59

Neuromodulation
Dopamine Rodent IA, nOR, Sptial working memory 66,67
NHP Delayed-non-match-to-sample 64
Glucocorticoids
    Corticosteroid Rodents IA, nOR 69,72
Humans Cued-fear conditioning 69
Noradrenaline Rodents AFC, IA 73
Amphetamines
    Methylphenidate Humans Delayed Recall, Spatial working memory, Sustained Attention 10,75,76
Acetylcholine Rodent MWM, Radial Arm Maze 77
    Donepezil Human cognitive scales and examinations 78

Endogenous
Glucose Rodent IA 84
Human Verbal Episodic Memory 83
Insulin Rodent Radial Arm Maze 85
Human Delayed score recall 86,87

Behavioral
Reconsolidation Rodent IA, AFC, CFC 28,98,99,100
Exercise Rodent MWM, IA, nOR 94