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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Eur J Neurosci. 2012 Sep 26;36(12):3615–3627. doi: 10.1111/ejn.12002

Figure 8. High threshold calcium channels and calcium-induced calcium release underlie tLTD but not tLTP.

Figure 8

A Representative example of effects of 5 µM thapsigargine, 5 µM nifedipine and 10 µM ryanodine on MSNs plasticity. Top panels show EPSP amplitude measured every 20 sec before and after induction. Dark horizontal bars show where amplitude of averaged EPSPs was measured. Middle and Bottom panels show input resistance and RMP throughout recordings. B Effects of tharpsigargine (triangles), nifedipine (squares) and ryanodine (circles) on MSNs plasticity. Symbols above broken line indicate tLTP. Note that only one or two MSNs undergo tLTD in all experimental conditions. C Averaged effects of the drugs on MSNs plasticity. Values are expressed as % of control ± SEM. D Representative tLTD (left panel) and tLTP (right panel) in presence of 10 µM KN-93 in recording pipette. E Effects of 10 µM KN-93 on long-term plasticity of 13 MSNs. Averaged effects on STDP, in presence (KN-93; open symbols) and absence (control; solid symbols) of the drug, are shown as % of control ± SEM.