. Author manuscript; available in PMC: 2012 Dec 21.

Published in final edited form as: Future Microbiol. 2010 Oct;5(10):1493–1506. doi: 10.2217/fmb.10.107

Table 2.

Major roles of proteins expressed by high risk HPV.

Protein	Role in the virus life cycle
E1	Genome replication: ATP-dependent DNA helicase.
E2	Genome replication, transcription, segregation, encapsidation. Regulation of cellular gene expression. Cell cycle and apoptosis regulation.
E4	Remodels cytokeratin network. Cell cycle arrest. Virion assembly.
E5	Control of cell growth and differentiation. Immune modulation
E6	Oncoprotein. Inhibits apoptosis and differentiation. Regulates cell shape, polarity, mobility and signalling.
E7	Cell cycle control. Controls centrosome duplication.
L1	Major capsid protein
L2	Minor capsid protein. Recruits L1. Virus assembly.