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. 2012 Nov 1;287(52):43565–43572. doi: 10.1074/jbc.M112.401760

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Stimulation of EGFR and blockade of E-cadherin induce mesenchymal phenotype and exosomal TF emission in DLD-1 cells. A, stimulation of DLD-1 colorectal adenocarcinoma cells with SHE78-7 antibody and TGFα provokes cell scattering, elongation, and mesenchymal appearance. B, marked release of TF into conditioned medium of DLD-1 cells stimulated with the SHE/TGFα mixture (TF ELISA) (n = 3) (*, p < 0,05). C, increase in production of exosomal-like EVs by DLD-1 cells stimulated with SHE78-7 and TGFα (n = 2) (*, p < 0.05).