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. 2012 Oct 31;287(52):43639–43650. doi: 10.1074/jbc.M112.393678

FIGURE 1.

FIGURE 1.

Glycolysis inhibition suppresses HuR expression at the protein level in prostate cancer cells. A, Western blot (left panel) and qRT-PCR (right panel) analyses of the effect of glucose deprivation on the protein and mRNA expression levels of HuR in LNCaP, PC-3, and DU-145 cells in 10% FBS-supplemented, glucose-free RPMI 1640 medium for 72 h. B, Western blot (upper panel) and qRT-PCR (lower panel) analyses of dose- and/or time-dependent effects of CG-5 and 2-DG on the protein and mRNA expression levels of HuR in LNCaP cells. C, dose-dependent effects of CG-5 on HuR protein expression in PC-3 and DU-145 cells after 48 h of exposure.