TABLE 2.
Demographic, physiological, and clinical characteristics of CST G364S genotypes
Data are presented as the mean ± S.E. BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; MAP, mean arterial pressure; LVIDd, left ventricular dimension at end diastole; LVIDs, left ventricular dimension at end systole; The glucose values were random plasma glucose levels. Statistical significance for Gly/Ser and Ser/Ser genotypes were tested with respect to the Gly/Gly genotype. The significantly differing parameters are shown in bold.
| Parameters | Gly/Gly | Gly/Ser | Ser/Ser |
|---|---|---|---|
| Demographic/Physical | |||
| Age (years) | 39.2 ± 0.3 (n = 858) | 38.4 ± 0.8a (n = 144) | 33.7 ± 2.6a (n = 8) |
| Sex (male/female) | 67/33% | 66/34% | 56/44% |
| Hypertensives/normotensives | 44/56% | 47/53% | 56/44% |
| Height (cm) | 163.4 ± 0.3 (n = 858) | 163.3 ± 0.7a (n = 144) | 160.4 ± 2.9a (n = 8) |
| Weight (kg) | 65.0 ± 0.3 (n = 858) | 65.1 ± 0.9a (n = 144) | 57.4 ± 2.5a (n = 8) |
| BMI (kg/m2) | 24.5 ± 0.2 (n = 858) | 24.3 ± 2.6a (n = 144) | 22.4 ± 1.3a (n = 8) |
| Physiological | |||
| SBP (mm Hg) | 139.6 ± 0.8 (n = 809) | 142.6 ± 1.9a (n = 132) | 134.0 ± 14.8a (n = 5) |
| DBP (mm Hg) | 83.9 ± 0.4 (n = 809) | 85.0 ± 1.0a (n = 132) | 84 ± 7.5a (n = 5) |
| MAP (mm Hg) | 102.3 ± 0.5 (n = 810) | 104.7 ± 1.2a (n = 127) | 100.6 ± 9.8a (n = 5) |
| Heart rate (beats/min) | 76.6 ± 0.3 (n = 843) | 76.2 ± 0.6a (n = 141) | 72.4 ± 1.6a (n = 7) |
| LVIDd (mm) | 44.7 ± 0.1 (n = 824) | 45.1 ± 0.3a (n = 139) | 45.1 ± 1.3a (n = 8) |
| LVIDs (mm) | 27.1 ± 0.1 (n = 820) | 27.5 ± 0.3a (n = 135) | 27.2 ± 1.2a (n = 8) |
| Biochemical | |||
| Hemoglobin (g/dl) | 13.3 ± 0.05 (n = 789) | 13.6 ± 0.13b (n = 133) | 13.0 ± 0.33a (n = 7) |
| Sodium (meq/liter) | 137.1 ± 0.2 (n = 799) | 137.8 ± 0.3a (n = 129) | 138.7 ± 1.3a (n = 8) |
| Potassium (meq/liter) | 3.99 ± 0.01 (n = 795) | 3.96 ± 0.02a (n = 133) | 3.97 ± 0.09a (n = 7) |
| Urea (mg/dl) | 24.0 ± 0.3 (n = 800) | 24.9 ± 0.7a (n = 137) | 23.4 ± 2.6a (n = 8) |
| Creatinine (mg/dl) | 0.84 ± 0.01 (n = 807) | 0.88 ± 0.01a (n = 137) | 0.81 ± 0.07a (n = 7) |
| Glucose (mg/dl) | 93.2 ± 0.5 (n = 748) | 97.7 ± 1.5b (n = 135) | 96.9 ± 10.9a (n = 7) |
| Total cholesterol (mg/dl) | 167.4 ± 1.1 (n = 784) | 165.4 ± 2.6a (n = 126) | 170.0 ± 15.4a (n = 8) |
| Triglycerides (mg/dl) | 121.7 ± 1.7 (n = 695) | 132.7 ± 4.5b (n = 131) | 158.4 ± 19.4b (n = 8) |
| HDL (mg/dl) | 37.3 ± 0.3 (n = 789) | 38.2 ± 0.5c (n = 134) | 49.2 ± 6.9c (n = 8) |
| LDL (mg/dl) | 99.8 ± 0.9 (n = 777) | 103 ± 2.2a (n = 130) | 83.6 ± 11.0a (n = 8) |
| Epinephrine (pg/ml) | 66.2 ± 5.5 (n = 62) | 46.2 ± 2.8b (n = 66) | 47.0 ± 13.6a (n = 6) |
| Norepinephrine (pg/ml) | 231.6 ± 17.2 (n = 68) | 169.7 ± 10.4c (n = 71) | 111.1 ± 16.2c (n = 6) |
a Not significant.
b p < 0.05.
c p < 0.01.