TABLE 2.

Thermodynamic parameters for cyclotide binding to different membrane systems

System	n	Ka	ΔH	ΔG	ΔS
		103m−1	kcal/mol	kcal/mol	cal/mol/K
DPC
kB1	5.19 ± 1.03	1.70 ± 0.14	−0.86 ± 0.02	−6.90 ± 0.05	19.93 ± 0.09
kB2	6.29 ± 0.82	5.85 ± 0.35	−0.70 ± 0.07	−7.64 ± 0.04	22.91 ± 0.10
PC/PE (5:2)
kB1	1.94 ± 0.50	163.00 ± 37.75	−1.39 ± 0.16	−9.63 ± 0.14	27.20 ± 0.44
T27A	1.60 ± 0.13	68.90 ± 24.18	−1.20 ± 0.09	−9.11 ± 0.22	26.11 ± 1.01
kB2	2.43 ± 0.33	246.50 ± 136.05	−2.11 ± 0.09	−9.82 ± 0.33	25.47 ± 1.16
PC/PE (6:1)
kB2	4.23 ± 0.29	48.00 ± 8.49	−1.33 ± 0.11	−8.90 ± 0.11	24.98 ± 0.71
PC/PE (4:3)
kB2	1.54 ± 0.07	416.00 ± 62.23	−3.11 ± 0.09	−10.20 ± 0.09	23.40 ± 0.01
PC/PE (5:2) at 20 °C
kB2	2.13 ± 0.23	172.00 ± 53.74	−1.26 ± 0.02	−9.34 ± 0.18	27.59 ± 0.71
PC/PE (5:2) at 40 °C
kB2	2.15 ± 0.06	349.00 ± 12.73	−2.95 ± 0.02	−10.44 ± 0.02	23.91 ± 0.02