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Mutant p53 up-regulates the Axl promoter in H1299 cells. H1299 cells were transfected with 200 ng of a pGL3 basic vector containing the Axl promoter upstream of the luciferase reporter gene and 1 ug of the indicated p53 expression plasmid. Cell lysates were prepared 48 hours after transfection, and luciferase activity was determined. Data are shown as fold activation over the control. Experiments were performed in triplicate. Error bars showing standard deviations are indicated.
