Table 1.
H1299 Cells Expressing Transactivation-Deficient Mutant p53-D281G (L22Q/W23S) Are Efficient in Up-Regulating Mutant p53 Targets
| Symbol | Fold over the control | P value | Gene |
|---|---|---|---|
| ACTN4 | 5.47 | 0.001 | Actinin, α 4 |
| AXL | 7.04 | 0.0007 | AXL receptor tyrosine kinase |
| BTG1 | 0.49 | 0.0009 | B-cell translocation gene 1, antiproliferative |
| CDC25B | 0.51 | 0.001 | Cell division cycle 25B |
| EEF1A2 | 0.28 | 0.0008 | Eukaryotic translation elongation factor 1 α 2 |
| ERCC1 | 5.23 | 1.04E-05 | Excision repair cross-complementing rodent repair deficiency, complementation group 1 |
| ERCC2 | 2.85 | 0.003 | Excision repair cross-complementing rodent repair deficiency, complementation group 2 |
| ERF | 3.72 | 1.40E-05 | Ets2 repressor factor |
| FN1 | 0.27 | 0.002 | Fibronectin 1 |
| GARS | 5.26 | 0.002 | Glycyl-tRNA synthetase |
| GDI2 | 0.29 | 0.001 | GDP dissociation inhibitor 2 |
| GPR126 | 0.43 | 0.0001 | G protein–coupled receptor 126 |
| IGFBP6 | 17.25 | 0.0004 | Insulin-like growth factor binding protein 6 |
| PRAME | 0.28 | 0.0002 | Preferentially expressed antigen in melanoma |
| PRKAR1A | 0.19 | 8.78E-05 | Protein kinase, cAMP-dependent, regulatory, type I, α (tissue-specific extinguisher 1) |
| PSMB6 | 0.31 | 0.0002 | Proteasome (prosome, macropain) subunit, β type, 6 |
| RAB31 | 0.22 | 0.001 | RAB31, RAS oncogene family member |
| RELB | 4.77 | 3.82E-05 | v-Rel |
| SRPX | 0.37 | 0.0009 | Sushi repeat–containing protein, X-linked |