Table I.
Comparison between signalling and cytoskeletal molecules involved in circular dorsal ruffles and podosome rosettes.
| Circular dorsal ruffles | Podosome rosettes | |
|---|---|---|
| PI signalling | ||
| PI3K | Yes (57) | Yes (58) |
| PIs 5-phosphatase | SHIP2 (15) | Synaptojanin 2 (58) |
| Accumulation of PI(3,4)P2 | Yes (15) | Yes (58) |
| PI(3,4)P2-binding proteins | TAPP1 (15, 68) | Tks4 (60), Tks5 (58, 61) |
| Small GTPase | ||
| Arf | Arf1, 5 (10) | Arf6 (56) |
| Rac | Yes (7, 43) | Yes (50, 58) |
| Rho | Yes (47) | Yes (62) |
| Actin machinery | ||
| Arp2/3 | Yes (11) | Yes (51) |
| N-WASP | Yes (29) | Yes (53) |
| WAVE | Yes (13) and No (29) | No (58) |
| Cytoskeletons other than actin | ||
| Microtubules | Yes (our unpublished results) | No (62) [Yes for podosome belts (51)] |
| Intermediate filaments | unknown | Yes (62) |