Tab. 4.
Mean Pharmacokinetic parameters of Letrozole in Wistar Rat (n= 6) after oral administration of 10 mg Kg−1 body weight
| Parameters | Compartmental Model | Non-Compartmental Model |
|---|---|---|
| Cmax (μg mL−1) | 88.82 | – |
| Tmax (h) | 8.9 | – |
| K (h−1) | 0.06 | 0.06 |
| t1/2(h) | 10.76 | – |
| AUC0–t (μg h mL−1) | 2259.95 | – |
| AUC0–∞ (μg h mL−1) | 2287.58 | – |
| Volume of distribution (L) | 0.0127 | – |
| AUMC0_t (μg h2 mL−1) | – | 41904.11 |
| AUMC0–∞ (μg h2 mL−1) | – | 44913.53 |
| MRT (h) | – | 19.6 |
Cmax= peak serum concentration; Tmax= time to reach peak concentration; K= Elimination rate constant; t1/2= Half-life; AUC0–t= area under the curve from zero to t; AUC0–∞= area under the curve from zero to infinite; L= Volume of distribution; AUMC0_t= area under the moment curve from zero to t; AUMC0–∞= area under the moment curve from zero to infinite; MRT= mean residence time.