Table 4.
LF epitopes defined by the 50 most reactive decapeptides. Designations are as in Table 3. Results shown are from one experiment. A separate, independent experiment confirmed that non-MHC class II genetic background-dependent LF epitopes are more frequent than MHC class II-dependent LF epitopes.
| Epitope number | Decapeptide number | Sequence | Amino acid number | Reactive strain |
|---|---|---|---|---|
| 1 | 19–20 | HGDVGMHVKEKE | 37–48 | B6.H2k, B6 (Background) |
| 2 | 23–25 | KEKEKNKDENKRKD | 45–58 | B6.H2k, B6 (Background) |
| 6 | 74–75 | LHEHYVYAKEGY | 147–158 | A/J (Background) |
| C | 145–146 | LEELKDQRMLAR | 289–300 | A/J (Background) |
| E | 191–193 | SLSEEEKELLNRIQ | 381–394 | B6.H2k, B6 (Background) |
| 11 | 201–203 | LSEKEKEFLKKLKL | 401–414 | B6.H2k, B6 (Background) |
| 12 | 209–210 | QPYDINQRLQDT | 417–428 | A/J (Background) |
| 20 | 372–373 | NSKKFIDIFKEE | 743–754 | A/J (Background) |
| 21 | 393–394 | RLKVQKNAPKTF | 785–796 | A/J (Background) |
| 9/17 (53%) | ||||
| 4 | 49–51 | EKVPSDVLEMYKAI | 97–110 | A/J, B6, B6.H2k (Common) |
| 7 | 134–135 | QLYAPEAFNYMD | 267–278 | A/J, B6, B6.H2k (Common) |
| 9 | 172–174 | SLSQEEKELLKRIQ | 343–356 | A/J, B6, B6.H2k (Common) |
| 10 | 182–183 | LSTEEKEFLKKL | 363–374 | A/J, B6, B6.H2k (Common) |
| 4/17 (23%) | ||||
| A | 109–110 | DGQDLLFTNQLK | 217–228 | B6 (MHCII) |
| B | 141–142 | NEQEINLSLEEL | 281–292 | B6 (MHCII) |
| 16 | 330–331 | NGRFVFTDITLP | 659–670 | A/J, B6.H2k (MHCII) |
| 17 | 336–339 | NIAEQYTHQDEIYEQV | 671–686 | A/J, B6.H2k (MHCII) |
| 4/17 (23%) | ||||
| 3 | 32–33 | KTQEEHLKEIMK | 63–74 | B6.H2k |
| 5 | 66–69 | SEDKKKIKDIYGKD | 131–146 | A/J, B6 |
| D | 167–168 | IEPKKDDIIHSL | 333–344 | B6.H2k |
| 13 | 216–217 | LIDSPSINLDVR | 431–442 | A/J, B6 |
| 18 | 347–348 | VPESRSILLHGP | 693–704 | B6.H2k |