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. 2013 Jan;27(1):313–321. doi: 10.1096/fj.12-213454

Figure 5.

Figure 5.

Hepatic ATGL knockdown alters substrate utilization in DIO mice. A) ASM production from mitochondria incubated with [1-14C]palmitate (n=4). B) Liver glycogen levels in mice fed a control or HF diet for 12 wk (n=6–8). C) Cell suspensions isolated from liver tissues of control or Atgl shRNA-treated mice fed a control diet were incubated with radiolabeled glucose to measure glucose oxidation (n=4). D, E) mRNA abundance of glucokinase (Gk; D) and pyruvate dehydrogenase kinase 2 (Pdk2; E) (n=6–8). *P < 0.05 vs. control shRNA group; #P < 0.05 vs. control diet group.