Fig. 6.

Changes in methylation are specific to white matter. a. Quantification of KL protein expression in hippocampus normalized to β-tubulin (n = 6 young, n = 5 old animals; Student’s t-test). b. The overall level of methylation between young and old was determined by comparing the average % methylation for each monkey. No change was observed in old monkeys relative to young monkeys (mean ± S.E.M.; n = 6 young, n = 5 old animals; Student’s t-test). c. The % methylation for each CpG residue was evaluated between young and old animals. Four of five significant CpGs were hypomethylated in old animals (mean ± S.E.M.; Student’s t-test, *p ≤ 0.05)