Fig. 2.

Mechanism of immunosuppression of T cell activation by GCs. Schematic representation of TCR signaling process subdivided into two sides. Left sides present normal signaling through which IL-2 gene expressed. But, on right sides it is seen that GRs mediated TCR signaling where the intracellular membrane signal complex is negatively (−) regulated and consequently the tuned innermembrenal complex loosening their relation results in TCR signal impairment, through this IL-2 gene expression is retarded (X)