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Mechanism of muscle protein synthesis inhibition by GCs. Generally PI3K phosphorylates phosphatidylinositol 4, 5-bisphosphate (PIP2) to PIP3 which follow the Akt/PKB pathways for protein synthesis. But stress induced activated GRs negatively (−) regulate PI3K and block (X) the phosphorylation of PIP2. Consequently, the normal pathway falls down and depletion of protein synthesis
