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Mechanism of GCs induced osteoporosis. The illustration represents two ways viz. bone resorption and bone matrix break down as a process for osteoporosis. Here, activated GRs positively (+) regulated MMP-13 and increased ejection of collagenase 3 which is responsible for bone matrix break down. On the other side, RANKL and MCSF positively (+) regulated and OPG is negatively (−) regulated by GRs. The both regulation induce bone resorption
