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. Author manuscript; available in PMC: 2012 Dec 21.
Published in final edited form as: Mamm Genome. 2011 May 25;22(9-10):506–517. doi: 10.1007/s00335-011-9333-7

Figure 6.

Figure 6

Inactivation of p53 promotes spontaneous tumorigenesis in Mcm4chaos3/chaos3 mice, but a loss of p21 does not. A) Tumor-free survival curves of Trp53−/− and Trp53−/−;Mcm4chaos3/chaos3 mice. B) Tumor-free survival curves of Trp53+/− and Trp53+/−;Mcm4chaos3/chaos3 mice. C) An X-ray photo of an osteosarcoma observed in a Trp53+/−;Mcm4chaos3/chaos3 mouse. D) Tumor-free survival curves of p21+/−;Mcm4chaos3/chaos3 and p21−/−;Mcm4chaos3/chaos3 mice. All Trp53;Mcm4chaos3 experiments were performed in a B6 congenic background, whereas the p21;Mcm4chaos3 cancer study was conducted in a mixed background between B6 and C3H.