Fig. 4.
Up-regulation of senescence-associated genes in decidual NK cells. (A and B) GSEA of microarray data of decidual NK cells (30) compared with the molecular signature of oncogene ras-induced senescence (21). The transcriptional up-regulation of decidual NK cells versus peripheral blood CD56dim NK cells (A) and peripheral blood CD56bright NK cells (B) were analyzed separately. (C) List of senescence-associated genes up-regulated in decidual NK cells and in CD158d-stimulated resting NK cells, presented as fold change (F.C.) of expression in decidual NK (dNK) compared with peripheral blood NK (pNK) belonging to CD56dim or CD56bright subsets. ND, not detected.
