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. 2012 Nov 26;109(50):20596–20601. doi: 10.1073/pnas.1208248109

Fig. 5.

Fig. 5.

The senescence secretome induced by CD158d in NK cells increases vascular permeability and promotes angiogenesis. (A) Effect of CD158d-induced senescence secretome on vascular permeability. HUVEC were incubated with supernatants from resting NK cells stimulated with control or CD158d mAbs and permeability of the HUVEC monolayer is shown. (B) Effect of recombinant IL-1β and TNF-α on the permeability of HUVEC monolayers. (C) Representative images from the tube formation assay to test the effect of the CD158d-induced secretome. HUVEC seeded on a gel matrix were evaluated for their ability to form tubes in the presence of supernatants of NK cells stimulated for 16 h with either cIg or CD158d mAb. (D) Quantification of matrigel-tube formation assay in (C). The data are representative of experiments using NK cells from three independent donors.