Fig. 4.

BDNF overexpression selectively modifies instrumental action. (A) Consistent with the perspective that PL BDNF is sufficient to regulate motivation but not sensitivity to contingency degradation, BDNF overexpression in CORT-exposed mice nearly doubled break points. (B) The same manipulation, however, failed to rescue sensitivity to response-outcome contingency degradation in CORT-exposed mice, and BDNF infusion in naïve animals also eliminated behavioral flexibility. Bars represent means + SEM; *P < 0.05, **P < 0.001.