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. 2012 Nov 26;109(50):20602–20607. doi: 10.1073/pnas.1209294110

Fig. 3.

Fig. 3.

Pain-related behaviors develop progressively in wild-type mice after DMM surgery. (A) Mechanical allodynia in the ipsilateral hindpaw of naïve (n = 7–10), sham (n = 9), and DMM mice (n = 9–13), Naïve time 0: n = 30, one-way ANOVA with Bonferroni’s multiple comparison test, **P < 0.01, ***P < 0.001 vs. Time 0. Results show mean ± SEM. (B) Distance traveled, average number of climbs per hour, and average number of rears per hour during a 15-h period on a LABORAS platform. At 4 wk, n = 8 naïve, n = 10 DMM, P > 0.05 by two-tailed t test. At 8 wk, n = 18 naïve, n = 10 sham, n = 15 DMM, *P < 0.05 and **P < 0.01 by one-way ANOVA with Bonferroni’s multiple comparison test. At 16 wk, n = 9 naïve and n = 8 DMM, *P = 0.03 for distance, **P = 0.003 for climbing, and *P = 0.0487 for rearing by two-tailed t test. For LABORAS results, data were log-transformed if necessary to ensure normality as determined by the D’Agostino–Pearson normality test before analysis. Results show mean ± SEM.