Figure 3.

Representative histological sections. Representative histological sections of the five groups at 6 weeks. 1/Saline control. 2/Short soaking time. 3/Long soaking time. 4/Topical zoledronic acid, no rinse. 5/Zoledronic acid systemic injection at two weeks. Specimens are chosen to be representative of both median bone ingrowth distance and median bone density. The black line indicates the frontier between non-remodelled and remodelled graft bone and the bone ingrowth distance was less in group 3 compared to the other groups. Histologically, the increased bone volume fraction in the remodelled area can clearly be seen in all bisphosphonate treated groups.