Table 1.
Local graft treatment with bisphosphonate
| Study | Drug | Concentration | Soaking time | Rinse |
|---|---|---|---|---|
| Agholme 2009
[13] |
Alendronate |
2mg/ml |
10 min |
3x3 min/no |
| Aspenberg 2002
[10] |
Alendronate |
1 mg/ml |
10 min |
3x3 min |
| Baas 2008
[11] |
Pamidronate |
9mg/ml |
3 min |
No |
| Belfrage 2011
[6] |
Zoledronate |
0.5 mg/ml |
Topical |
No |
| Jakobsen 2007
[14] |
Alendronate |
2 mg/ml |
3 min |
No |
| Jakobsen 2010
[12] |
Zoledronate |
0.005/0.05/0.5 mg/ml |
3 min |
3 min |
| Jeppsson 2003
[15] |
Clodronate |
60 mg/ml |
10 min |
3x3 min |
| Kesteris 2006
[7] |
Clodronate |
60 mg/ml 10 ml |
3 min |
Washed 500 ml NaCl |
| Seo 2010
[16] |
Zoledronate |
30 μM, 10 ml |
5 min |
No |
| Tägil 2004
[5] |
Alendronate |
1 mg/ml |
10 min |
3x3 min |
| Tägil 2006 [17] | Zoledronate | 0.7 mg sc | * | - |
*Systemic injection of zoledronic acid to graft donor rat 24 hours before being euthanized.