Table 3. Pooled Analysis on Association between the MTHFR C677T polymorphism and the cervical lesion risk.

Genetic model	Number of study	Sample Size		Analysis	I2 (%)	Ph	Test of Association		P(Publication bias test)
		Case	Control	Model			P	OR(95%CI)	Begg’s test	Egger’s test
Total
Dominant model	16	3498	3594	R	78	0.00	0.95	0.99 [0.78, 1.26]	0.558	0.626
Recessive model	14	3233	3451	R	51	0.01	0.75	1.05 [0.80, 1.38]	0.827	0.956
Additive model	14	6177	6902	R	79	0.00	0.79	0.97 [0.80, 1.18]	1.000	0.659
CT vs. CC	14	2854	3097	R	69	0.00	0.75	0.97 [0.78, 1.20]	0.443	0.490
TT vs. CC	14	1927	2038	R	61	0.00	0.73	1.06 [0.76, 1.48]	0.913	0.614
Pathological type
ICC
Dominant model	12	2008	2932	R	73	0.00	0.62	0.94 [0.72, 1.21]
Dominant model*	11	1946	2855	R	73	0.00	0.44	0.90 [0.69, 1.18]
Recessive model	11	1946	2855	R	59	0.00	0.96	1.01 [0.70, 1.45]
Additive model	11	3915	5710	R	80	0.00	0.51	0.92 [0.73, 1.17]
CT vs. CC	11	1731	2534	R	64	0.00	0.29	0.88 [0.69, 1.12]
TT vs. CC	11	1229	1657	R	65	0.00	0.84	0.96 [0.62, 1.47]
SIL
Dominant model	11	1490	2916	R	71	0.00	0.54	1.09 [0.82, 1.45]
Dominant modelˆ	9	1287	2773	R	52	0.04	0.51	1.08 [0.86, 1.35]
Recessive model	9	1287	2773	F	0	0.79	0.80	1.03 [0.83, 1.27]
Additive model	9	2574	5546	R	43	0.08	0.59	1.04 [0.90, 1.21]
CT vs. CC	9	1123	2475	R	47	0.06	0.27	1.09 [0.94, 1.26]
TT vs. CC	9	698	1609	F	0	0.45	0.36	1.11 [0.88, 1.40]
Geographic area
Asian
Dominant model	9	1919	2081	R	80	0.00	0.71	1.07 [0.76, 1.49]
Recessive model	8	1777	2004	R	65	0.00	0.74	1.08 [0.70, 1.66]
Additive model	8	3242	4008	R	83	0.00	0.82	0.97 [0.71, 1.31]
CT vs. CC	8	1520	1770	R	72	0.00	0.72	0.95 [0.70, 1.28]
TT vs. CC	8	1064	1186	R	69	0.00	0.77	1.08 [0.65, 1.80]
European
Dominant model	4	1285	917	R	62	0.05	0.18	0.77 [0.52,1.13]
Recessive model	3	1162	851	F	0	0.89	0.13	0.79 [0.58,1.07]
Additive model	3	2347	1702	F	0	0.42	0.006	0.83 [0.72,0.95]
CT vs. CC	3	1066	764	F	30	0.24	0.05	0.83 [0.69,1.00]
TT vs. CC	3	688	471	F	0	0.82	0.05	0.73 [0.53,1.00]
USA
Dominant model	3	294	596	R	83	0.00	0.62	1.22 [0.56, 2.65]
Recessive model	3	294	596	F	0	0.72	0.25	1.39 [0.79, 2.45]
Additive model	3	588	1192	R	76	0.02	0.57	1.16 [0.70, 1.93]
CT vs. CC	3	268	563	R	83	0.00	0.74	1.15 [0.50, 2.63]
TT vs. CC	3	175	381	F	20	0.29	0.13	1.56 [0.88, 2.77]

Dominant model: CT+TT vs. CC; Recessive model: TT vs. CC+CT; Additive model: T vs. C; R, Random-effects model; F, fixed-effects model; ICC: invasive cervical cancer; SIL, squamous intra-epithelial lesion; Dominant model*: one study [27] omitted; Dominant modelˆ: two studies [27], [35] omitted.