Table 4. Pooled Analysis on Association between the MTHFR A1298C polymorphism and the cervical lesion risk.
| Genetic model | Number of study | Sample Size | Analysis | I2 (%) | Ph | Test of Association | P(Publication bias test) | |||
| Case | Control | Model | P | OR(95%CI) | Begg’s test | Egger’s test | ||||
| Total | ||||||||||
| Dominant model | 5 | 1087 | 1202 | R | 68 | 0.01 | 0.26 | 1.21[0.87, 1.69] | 0.462 | 0.290 |
| Recessive model | 4 | 945 | 1125 | F | 42 | 0.16 | 0.33 | 0.81[0.54, 1.23] | 1.000 | 0.992 |
| Additive model | 4 | 1890 | 2250 | F | 0 | 0.81 | 0.82 | 0.98[0.85, 1.14] | 1.000 | 0.587 |
| AC vs. AA | 4 | 912 | 1066 | F | 0 | 0.81 | 0.80 | 1.02[0.85, 1.24] | 1.000 | 0.930 |
| CC vs. AA | 4 | 597 | 717 | F | 37 | 0.19 | 0.31 | 0.80[0.52, 1.24] | 1.000 | 0.971 |
| Pathological type | ||||||||||
| ICC | ||||||||||
| Dominant model | 5 | 610 | 1202 | F | 0 | 0.63 | 0.06 | 1.21[0.99, 1.49] | ||
| Recessive model | 4 | 548 | 1125 | R | 51 | 0.10 | 0.46 | 0.67[0.24, 1.93] | ||
| Additive model | 4 | 1096 | 2250 | F | 0 | 1.00 | 0.43 | 1.07[0.90, 1.27] | ||
| AC vs. AA | 4 | 520 | 1066 | F | 0 | 0.62 | 0.09 | 1.21[0.97, 1.51] | ||
| CC vs. AA | 4 | 319 | 717 | F | 43 | 0.15 | 0.46 | 0.82[0.49, 1.38] | ||
| SIL | ||||||||||
| Dominant model | 4 | 477 | 1118 | R | 83 | 0.00 | 0.49 | 1.28[0.63, 2.60] | ||
| Recessive model | 3 | 397 | 1041 | F | 0 | 0.85 | 0.43 | 0.78[0.42, 1.44] | ||
| Additive model | 3 | 794 | 2082 | F | 0 | 0.90 | 0.14 | 0.85[0.68, 1.06] | ||
| AC vs. AA | 3 | 382 | 983 | F | 0 | 0.75 | 0.25 | 0.85[0.65, 1.12] | ||
| CC vs. AA | 3 | 278 | 658 | F | 0 | 0.86 | 0.34 | 0.74[0.40, 1.38] | ||
Dominant model: CC+AC vs. AA; Recessive model: CC vs. AC+AA; Additive model: C vs. A; R, Random-effects model; F, fixed-effects model; ICC, invasive cervical cancer; ICC: invasive cervical cancer; SIL, squamous intra-epithelial lesion.