Table 1. Summary of qMSP measurements for all samples (n = 285).
| Sample description | Percent demethylation, median (range) | ||
|---|---|---|---|
|
CD3Z |
FOXP3 |
FOXP3/CD3Z |
|
|
Bloods (n = 165) |
17.6 (2.1–44.4) |
0.8 (0.06–3.2) |
4.5 (0.9–20.2) |
| Controls (n = 94) |
21.7 (4.7–44.4) |
1.0 (0.2–3.2) |
4.8 (1.0–20.2) |
| Never smokers (n = 44) |
19.3 (4.7–32.1) |
1.0 (0.2–2.5) |
4.8 (1.0–11.7) |
| Former smokers (n = 42) |
22.4 (8.8–43.4) |
1.1 (0.2–2.2) |
4.4 (1.8–10.5) |
| Current smokers (n = 8) |
23.4 (5.7–44.4) |
1.6 (0.8–3.2) |
7.4 (3.6–20.2) |
| Glioma cases (n = 71) |
11.2 (2.1–37.7) |
0.5 (0.06–2.5) |
4.1 (0.9–14.8) |
| Never smokers (n = 31) |
11.3 (2.7–37.7) |
0.5 (0.06–2.5) |
3.8 (1.3–11.5) |
| Former smokers (n = 29) |
12.7 (3.3–32.8) |
0.5 (0.06–1.7) |
4.1 (0.9–12.8) |
| Current smokers (n = 11) |
9.6 (2.1–27.8) |
0.5 (0.1–1.2) |
5.1 (2.3–14.8) |
| Non-GBM (n = 6) |
18.5 (3.5–26.6) |
0.9 (0.2–1.6) |
6.0 (3.8–7.1) |
| GBM (n = 65) |
10.5 (2.1–37.7) |
0.5 (0.06–2.5) |
4.1 (0.9–14.8) |
|
Excised tumors (n = 120) |
0.5 (0.03–18.7) |
0.03 (0–1.5) |
5.1 (0–100) |
| Grades I, II and III (n = 83) |
0.3 (0.03–3.9) |
0.02 (0–0.5) |
3.4 (0–100) |
| Pilocytic astrocytoma (n = 2) |
1.4 (1.0–1.9) |
0 (0–0) |
0 (0–0) |
| Ependymoma (n = 15) |
0.5 (0.09–3.0) |
0.03 (0–0.3) |
3.4 (0–29.4) |
| Oligodendroglioma (n = 20) |
0.2 (0.04–1.6) |
0 (0–0.2) |
0 (0–57.3) |
| Oligoastrocytoma (n = 19) |
0.25 (0.04–3.9) |
0.05 (0–0.4) |
10.5 (0–100) |
| Astrocytoma (n = 27) |
0.3 (0.03–2.0) |
0 (0–0.5) |
0 (0–100) |
| Grade IV, GBM (n = 37) | 1.1 (0.17–18.7) | 0.08 (0–1.5) | 7.8 (0–47.4) |