Table 1. Clinical signs, pathological changes and virus replication in EV71-infected gerbils.
| Gerbils | Clinical signs | Days post infection | Pathological findings in spinal cords or brainstems | Virus titer (log10 TCID50/g) | ||
| Spinal cords | Brainstems | Skeletal muscles | ||||
| 1 | Hind limb paralysis, minimal movement, lethargy | 4 | Neuron swelling, neuronophagia, necrosis of neuron, glial cell hyperplasia | 8.5 | 7.6 | 8.5 |
| 2 | Hind limb paralysis, somemovement possible, tachypnea | 5 | Neuron swelling, necrosis of neuron, neuronophagia, axonal degeneration | 7.9 | 7.8 | 8.1 |
| 3 | Hunched posture, hind limbparalysis, minimal movement | 5 | Neuron swelling, neuronophagia, glial cell hyperplasia, necrosis of neuron | 8.3 | 8.1 | 7.8 |
| 4 | Hind limb paralysis, somemovement possible | 5 | Neuron swelling, glial cell hyperplasia | 8.2 | 7.5 | 8.2 |
Four 21-day-old gerbils were inoculated IP with a dose of 1×105.0 TCID50 EV71.