Table 1. Correlation between expression levels of p53 and clinicopathologic features of the individuals in three cohorts of gastric cancers treated with surgery alone.
| Variables | Training cohort (n = 82 cases) | Testing cohort (n = 374 cases) | Validation cohort (n = 365 cases) | ||||||
| Low (%) | High (%) | p a | Low (%) | High (%) | p a | Low (%) | High (%) | p a | |
| All patients | 46 (56.1) | 36 (43.9) | 232 (62.0) | 142 (38.0) | 147 (40.3) | 218 (59.7) | |||
| Age (years) | .272 | .222 | .197 | ||||||
| ≤65 | 34 (73.9) | 31 (86.1) | 143 (61.6) | 97 (68.3) | 58 (39.5) | 102 (46.8) | |||
| >65 | 12 (26.1) | 5 (13.8) | 89 (38.4) | 45 (31.7) | 89 (60.5) | 116 (53.2) | |||
| Gender | .800 | .729 | .254 | ||||||
| Males | 35 (76.1) | 26 (72.2) | 163 (70.3) | 97 (68.3) | 109 (74.2) | 173 (79.4) | |||
| Females | 11 (23.9) | 10 (27.8) | 69 (29.7) | 45 (32.7) | 38 (25.8) | 45 (20.6) | |||
| Depth of invasion | .379 | .002 | .043 | ||||||
| T1/T2 | 4 (8.7) | 1 (2.8) | 56 (24.1) | 16 (11.3) | 60 (40.8) | 66 (30.3) | |||
| T3/T4 | 42 (91.3) | 35 (97.2) | 176 (75.9) | 126 (88.7) | 87 (59.2) | 152 (69.7) | |||
| Lymph node metastasis | <.001 | <.001 | .021 | ||||||
| N0 | 19 (41.3) | 1 (2.8) | 87 (37.5) | 17 (12.0) | 67 (45.6) | 72 (33.0) | |||
| N1/N2/N3 | 27 (58.7) | 35 (97.2) | 145 (62.5) | 125 (88.0) | 80 (54.4) | 146 (67.0) | |||
| Distant metastasis | .003 | 1.000 | .173 | ||||||
| M0 | 43 (93.5) | 24 (66.7) | 221 (95.3) | 136 (95.8) | 144 (98.0) | 207 (95.0) | |||
| M1 | 3 (6.5) | 12 (33.3) | 11 (4.7) | 6 (4.2) | 3 (2.0) | 11 (5.0) | |||
| TNM stage | <.001 | <.001 | .057 | ||||||
| I | 8 (17.4) | 1 (2.8) | 35 (15.1) | 5 (3.5) | 47 (32.0) | 46 (21.1) | |||
| II | 15 (32.6) | 3 (8.3) | 62 (26.7) | 19 (13.4) | 35 (23.8) | 46 (21.1) | |||
| III | 18 (39.1) | 17 (47.2) | 107 (46.1) | 91 (64.1) | 62 (42.2) | 119 (54.6) | |||
| IV | 5 (10.9) | 15 (41.7) | 28 (12.1) | 27 (19.0) | 3 (2.0) | 7 (3.2) | |||
| Tumor diameter | .119 | <.001 | .334 | ||||||
| ≤5 cm | 27 (58.7) | 14 (38.9) | 111 (47.8) | 40 (28.2) | 88 (59.9) | 119 (54.6) | |||
| >5 cm | 19 (41.3) | 22 (61.1) | 121 (52.2) | 102 (71.8) | 59 (40.1) | 99 (45.4) | |||
| Histological typeb | 1.000 | .003 | .082 | ||||||
| Intestinal | 24 (52.2) | 18 (50.0) | 146 (62.9) | 66 (46.5) | 68 (47.2) | 82 (37.8) | |||
| Diffuse | 22 (47.8) | 18 (50.0) | 86 (37.1) | 76 (53.5) | 76 (52.8) | 135 (62.2) | |||
| JWA expression | <.001 | <.001 | <.001 | ||||||
| Low | 17 (37.0) | 33 (91.7) | 32 (13.8) | 134 (94.4) | 40 (27.2) | 145 (66.5) | |||
| High | 29 (63.0) | 3 (8.3) | 200 (86.2) | 8 (5.6) | 107 (72.8) | 73 (33.5) | |||
a
Two-sided Fisher’s exact tests.
b
Excluded 4 patients with mixed intestinal and diffuse types in validation cohort.