Table 2.

Iodolactonization of 6-Substituted-5(Z)-hexenoic Acids^a

entry	R	product	yieldb (%)	erc,d
ae	Ph	8a	89	99:1
bf,g	p-NC-C6H4	8b	88	99:1
cg	2-Np	8c	93	98.5:1.5
d	t-Bu	8d	98	98:2

^aReactions run on 0.1 mmol scale.

^bIsolated yield after column chromatography.

^cer determined by chiral HPLC.

^dAbsolute stereochemistry of 8a–d are based on analogy with 6c and 6e.

^eZ/E ratio of 7a, 14:1.

^fZ/E ratio of 7b, 20:1.

^gResults obtained after 38 h at −20 °C.