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c-Met kinase inhibitor (SU11274) inhibits MUC1 and EGF-driven cell scattering and invasive phenotype. MDA-MB-231-control cells (A) or a MDA-MB-231-MUC1 cells (B) were seeded in Matrigel. MDA-MB-231-MUC1 cells were treated with 10ng/mL EGF and DMSO (B) or 5 μM SU11274, a selective c-Met kinase inhibitor (C). Arrowheads indicate single cells, and arrows indicate branching. Images were taken after 8 days. Scale bar represents 50 μm.
