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. Author manuscript; available in PMC: 2013 Dec 21.
Published in final edited form as: ACS Chem Biol. 2012 Sep 14;7(12):1975–1983. doi: 10.1021/cb300392z

Figure 5. SPM-242, an S1P3-selective antagonist, is a bitopic antagonist.

Figure 5

(A) SPM-242 shifted the dose-response curve of S1P and CYM-5541 (ERK phosphorylation assay). (B) SPM-242 (concentrations ranging from 10−9.5 to 10−7 M) shifted the dose-response curve of CYM-5541 in a dose-dependent manner (NFAT β–lactamase reporter assay) (Mean ± SEM; n=3).