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. Author manuscript; available in PMC: 2014 Feb 15.
Published in final edited form as: Cancer. 2012 Sep 18;119(4):774–781. doi: 10.1002/cncr.27742

Figure 5.

Figure 5

Activation of Notch1 in vivo was closely associated with the expression of cleaved-PARP, an end product of apoptosis. Total protein lysates were isolated from HTh7 tumor xenografts of either chrysin-treated (n=10) or vehicle-treated mice (n=8) and then analyzed by Western blot for expression of NICD (120kD) and cleaved-PARP (89kD, lower band). Increased NICD expression was seen in the treatment group together with induction of cleaved-PARP (shown in all tissue samples: “T” indicated samples from treatment group and “C” was from control group). Equal protein loading was confirmed using β-actin.